Evolution of the Mutation Spectrum Across a Mammalian Phylogeny.

When we performed Mantel tests on the spectrum of 3-mer mutation types partitioned into categories that experience different modalities of gBGC-induced selection (neutral A > T and C > G; negatively selected C > A and C > T, and positively selected A > C, A > G), we found highly significant phylogenetic signal within each category, notably including the gBGC-neutral (A > T + C > G) category ( supplementary Fig.

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