Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.

A subtext was to address whether a regimen incorporating radiotherapy with a proven locoregional effect was required in an era with an increasing trend for radical en-bloc surgery and lymphadenectomy, and whether perioperative chemotherapy might have advantages through a reduction in rates of systemic failure.

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