Curcumin-primed periodontal ligament stem cells-derived extracellular vesicles improve osteogenic ability through the Wnt/β-catenin pathway.

Comparing the PDLSC-EV and Cur-PDLSC-EV groups, there were extremely significant differences in COL1 and ALP gene expression ( p < 0.01) ( Figure 3D ). 3.5 Effect of Cur-PDLSC-EV on the Wnt/β-catenin pathway According to the Western blotting data, it was shown that Cur-PDLSC-EV upregulated the protein expression of p- GSK3β and β-catenin in PDLSCs.

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