PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.

Importantly, we observed a high correlation (R = 0.86, P -value < 0.001) on the level of directionality and magnitude of affected genes following knockout of PAXIP1 and STAG2 (Figure 4B and Supplementary Figure 4A ), with a highly significant ( P- value < 2.2e–16) overlap in the transcriptional changes in GC-treatment conditions ( Supplementary Fig 4B ).

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