DNA Hypomethylation in the TNF-Alpha Gene Predicts Rheumatoid Arthritis Classification in Patients with Early Inflammatory Symptoms.

We first confirm the highly significant difference in DNA methylation between HC and RA in purified CD4+ T-cells ( Figure 1 E, data for the TNF assay, HC (n = 5) and RA (n = 6), p = 0.002).

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There was no correlation between methylation levels of the TNF gene and any demographic or clinical variables, with the exception of age, which showed a weak trend for reduced methylation with age (rho = −0.440).

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