Multiple Sclerosis-Associated Gut Microbiome in the Israeli Diverse Populations: Associations with Ethnicity, Gender, Disability Status, Vitamin D Levels, and Mediterranean Diet.

A clinical trial on omega-3 and omega-6 supplement on clinical outcome in PwMS showed a positive trend in favor of patients treated with omega-3 [ 82 ].

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Differential abundance analysis (Kruskal–Wallis) revealed 485 KOs that differed between PwMS and HCs at FDR < 0.1, and these mapped significantly to nine KEGG pathway network maps, the highly significant top hit being biosynthesis of amino acids (FDR = 1.55 −19 ), while other pathways included 2-Oxocarboxylic acid metabolism, Peptidoglycan biosynthesis, Pyrimidine metabolism, Alanine, aspartate, and glutamate metabolism, etc.

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