Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in <i>Streptococcus pneumoniae</i>.

Proc Natl Acad Sci U S A · 2023 · PMC10576035 · PMID 37796984

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closest p

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highly significantno p-value reported

Whilst historically highly significant, the abundance of these serotypes has reduced in the population recently due to the introduction of the vaccine.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.