Furthermore, the energy expenditure analysis using CLAMS showed a highly significant increase at oxygen consumption, carbon dioxide production and total energy expenditure in AAV‐NLS‐PGC1α4‐injected mice compared with controls group, while maintaining food intake and locomotor activity (Figure 5d,f and Figures S7A , S7B ).
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AAV-Mediated nuclear localized PGC1α4 delivery in muscle ameliorates sarcopenia and aging-associated metabolic dysfunctions.
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