Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response.

Eight-month-old APP/PS1 mice who received 5 mg/kg of FK506 delivered IP on alternate days for 60 days showed highly significant decreases in CN activity (~ 31%) with synaptic protein preservation, reduced neuroinflammation, and plaque burden [ 34 ].

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