Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast.

The optimal values of a = 0 and b = 4,790 resulted in a highly significant model fit ( F = 44.94, df = 4, 51, P < 10 –15 ) with an r 2 value of 0.78, and the selected regions overlap the ddPCR probe locations ( figs. 1 and 2 ).

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We find a marginally significant negative effect of MA generations ( t = −2.002, P = 0.046) and a significant effect of RDH54 status, with rdh54 Δ strains exhibiting lower CN ( t = −3.893, P = 1.31 × 10 –4 ).

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