Posaconazole and midostaurin in patients with FLT3-mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study.

WHAT QUESTION DID THIS STUDY ADDRESS? Three questions were addressed: (i) how often would PK concerns make the hematologist replace PCZ with other antifungals, (ii) what is the actual magnitude of PCZ‐midostaurin interactions, and (iii) do PK interactions introduce unacceptable toxicities? WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE? In a prospective, multicenter, real‐life study in which the hematologist was blinded to PK findings, there was a highly significant deviation from guidelines, such that 16 out of 35 patients were treated with micafungin in place of PCZ.

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