Meanwhile, compared with the TAC/AAV Scramble-shRNA group, the IVSd and LVPWd decreased, and the myocardial systolic function EF% and FS% increased in the TAC/AAV CD9-shRNA group (although the EF% was not statistically different, there was an increasing trend, probably because the sample size was small).
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CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
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