Interestingly, baseline PC eigengene level did not show a significant correlation with longitudinal changes in skin thickness (MRSS), an endpoint that TCZ treatment failed to significantly impact in both the clinical trials, although there was a nonsignificant trend for a baseline correlation between PC score and MRSS.
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An interleukin 6 responsive plasma cell signature is associated with disease progression in systemic sclerosis interstitial lung disease.
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