borderline significancep = 0.06
In addition, the association reported at borderline significance between genetically predicted HDL-C and MDD in the univariable MR model (OR ivw =0.97, 95% CI = 0.95–1.001, p = 0.06) was enhanced in the MVMR model (OR = 0.98, 95% CI = 0.95–0.998, p = 0.03).In contrast, the connotations between genetically expected TC, LDL-C and MDD, the relations between genetically anticipated TG, LDL-C and AD, and the association among genetically expected LDL-C and AD observed in the univariable MR model were diminished and no longer significant in the MVMR model.