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UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.

Cancer Med · 2023 · PMC10587983 · PMID 37755128

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an increasing trendno p-value reported
26 During DNA damage, the expression of P53 showed an increasing trend. 27 The ubiquitin proteasome system plays an important role in the proteolysis of P53, which occurs through the UBC13‐mediated polyubiquitin chain. 28 UBC13 is linked to p53 and increases the cytoplasmic pool of monomeric p53 to restrain the formation of nuclear tetramerization of p53. 29 This study showed that knockdown of UBE2V2 upregulated the expression of P53 in SPCA1 and A549 cells by WB.

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