Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers.

While MBD is also known to decrease with age 21 , we did not observe any correlation between age and peri-tumoral subtype within our 8 patients, likely since all patients are post-menopausal and above 50 years of age, although a positive trend between age and adipose-related gene expression was observed in a larger cohort of normal breast samples from healthy women (Supplementary Fig. 3d ).

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