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Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution.

Front Toxicol · 2023 · PMC10598764 · PMID 37886123

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an encouraging trendno p-value reported
Our analysis also identified an encouraging trend in the reduction of animal-based studies focused on the impact of air pollution on skin pigmentation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.