IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.

Nat Commun · 2023 · PMC10600173 · PMID 37880243

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In addition, gene ontology analysis of the downregulated genes between IDH1mut samples and IDH1wt samples from GSE109857 revealed a highly significant enrichment of genes related to innate immune responses, such as granulocyte chemotaxis, antimicrobial humoral response, and regulation of B cell proliferation (Supplementary Fig. 1a ).

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