Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.

Front Cell Dev Biol · 2023 · PMC10601989 · PMID 37900280

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0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.001actually significant

Both compounds behave as permeant blockers of the hair-cell MET channel, with 13551 being the most efficient blocker of all tested at −60 mV, and both exhibited a highly significant ( p < 0.001, Supplementary Table S2 ) increase in loading relative to 13550 in mouse cochlear cultures.

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