Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin.

While Munc18a substantially stimulated membrane fusion with syntaxin1A [ 21 , 24 ], Munc18a produced a small, barely significant improvement in fusion mediated by SNARE complexes containing wild-type syntaxin3B when compared to wild-type syntaxin3B-containing SNARE complexes alone (compare Figure 1 D and Figure 3 D, blue bars; without Munc18: 4.92 ± 0.15; with Munc18: 5.76 ± 0.18; n = 4; p = 0.0471; one-way ANOVA followed by Tukey’s multiple comparisons).

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