We speculate that the effect of melatonin on the reduction of hepatic fatty acid production at the mRNA expression levels of PPAR and CPT-1 is not consistent with previous studies for the following reasons: Compared with HFD-induced obese animal models, D-Gal-induced mice show less weight gain and changes in the liver index, suggesting that the effect of melatonin on regulating fatty acid oxidation pathways may not be significant.
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