Clinical Cases and the Molecular Profiling of a Novel Childhood Encephalopathy-Causing <i>GNAO1</i> Mutation P170R.

In another study where we evaluated the molecular defects of 16 pathogenic Gαo variants, there is a highly significant correlation in Gβγ interaction with mutant Gαo determined using two independent methods: (i) co-IP using Gαo Gly92 -GFP and (ii) Gβγ displacement in BRET assay using non-tagged Gαo [ 13 ].

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