Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17.

In the stationary beam test, HET animals covered a lower number of segments (58/2: 6 months t(34) = 3.360, p = 0.002; 9 months, borderline significant; 12 months t(20) = 3.929, p = 0.001; 58/4: 3 months t(9) = 4.236, p = 0.002; 6 months t(20) = 3.403, p = 0.003; 9 months t(15) = 2.916, p = 0.010; 12 months t(16) = 2.916, p = 0.010), thus traveling a shorter distance, and had a higher number of falls than WT animals ( Table 1 ).

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