Differential Immune-Modulating Activities of Cell Walls and Secreted Metabolites from Probiotic <i>Bacillus coagulans</i> JBI-YZ6.3 under Normal versus Inflamed Culture Conditions.

In contrast, the two highest doses of the metabolite fraction induced highly significant increases in CD25 expression in the monocyte population compared to untreated control cultures ( p < 0.01; Figure 2 D).

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This increase in RANTES production was highly significant for the germinated spores ( p < 0.01) and significant for the cell wall fraction ( p < 0.05); moreover, a statistical trend for the metabolite fraction was observed, suggesting that both the cell walls and metabolites contributed to the effects observed in the germinated spores ( Figure 5 D).

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