Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.

Cardiovasc Diabetol · 2023 · PMC10612302 · PMID 37891556

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considerably significantno p-value reported

A considerably significant role had been ascribed to IGF-1R, inhibition of which holds the potential to ameliorate DKD by impeding pathological transformations via the regulation of Snail1 or SOCS2 expression [ 36 , 37 ].

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