marginally significantP = 0.058
Interestingly, 1 memory B cell subcluster (C2) with relative upregulation of MALAT1 , which was reported to be associated with viability of diffuse large B cell lymphoma (DLBCL) cell, 39 and TXNIP , which is required for expansion of germinal center B cell, 40 showed marginally significant depletion in IST non-responders ( P = 0.058; Figure 6 C–E).