Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways.

Intriguingly, the administration of AZIL.L or H + AD-MSCs exhibited considerably significant inhibitory action on the expression levels of p-JNK1/2/total JNK1/2, p-ERK1/2/total ERK1/2, p-P38/total P38, Bax, and cleaved caspase-3 proteins as well as an increasing effect on Bcl-2 protein expression level compared to groups treated with monotherapy ( Figure 6 ). 3.6.

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