Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-4.

Globally, as the PCA and the heatmap underlined it, there were more genes commonly shared by KD_N4 and CTRL than between KD_N1 and each of the two other conditions, suggesting once again that KD_N4 and CTRL might have a close transcriptomic signature in response to shear (the most common pathway being the EIF2 signaling that is highly significant and has a high z-score in both KD_N4 and CTRL conditions).

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