Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures.

We found, in all cell lines analysed, a weak trend towards increasing clone dominance and decreasing diversity over time, as shown by the positive slope of the linear fit to the average H–H indexes, and a negative slope in the case of Shannon indexes, respectively (Fig. 2 e–g and Fig.

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Moreover, there appeared to be an increasing trend in terms of clone size heterogeneity, but only the HACAT co-culture experiments demonstrated a statically significant increase (Fig.

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