Hepatic ketogenesis intermediates Aceto-Acetyl-CoA and HMG-CoA showed a nonsignificant trend toward lower expression in Fbxw7-null livers (Supplementary Fig. 6k ), likely because they are also involved in the mevalonate pathway.
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Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice.
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