D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels.

Transl Psychiatry · 2023 · PMC10620401 · PMID 37914710

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extremely significantno p-value reported

Therefore, the identification of novel antidepressant effect targets, especially those that regulate both BDNF-dependent rapid antidepressant action and serotonergic neurotransmission-mediated long-lasting antidepressant effect, is extremely significant for depression prevention and treatment.

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