RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling.

Front Mol Neurosci · 2023 · PMC10620725 · PMID 37928069

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Depletion of Neogenin, however, resulted in a highly significant 63 to 69% reduction in mature mushroom spines and a concomitant 52–68% increase in the proportion of immature thin spines (shNeo12, shNeo15, respectively; Figures 2C , E , F ).

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