Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential <i>in vivo</i>.

Mol Ther Nucleic Acids · 2023 · PMC10622308 · PMID 37928443

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highly significantno p-value reported

Treatment with Cpd.3 for 4 weeks starting on day 30 resulted in a subsequent stop in progression of the degenerative process and a highly significant improvement of DHI after 90 days compared with the vehicle group (83% vs. 72%; Figure 6 H).

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