A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.

Nat Commun · 2023 · PMC10622455 · PMID 37919281

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an elevated trendno p-value reported

In addition to early tau markers, the more advanced stage marker pThr231-tau (antibody AT180) was also elevated, and the late stage marker pSer202/Thr205-tau (antibody AT8) showed an elevated trend in J20;GT (Supplementary Fig. 8b ).

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highly significantno p-value reported

REST overexpression had a highly significant effect on Aβ deposition in the hippocampus, reducing Aβ plaque burden by 63% (Fig. 9h, i ).

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