Estimating the disutility of relapse in relapsing-remitting and secondary progressive multiple sclerosis using the EQ-5D-5L, AQoL-8D, EQ-5D-5L-psychosocial, and SF-6D: implications for health economic evaluation models.

Overall, we observed an increasing trend of relapse disutilities from ‘mild’ to ‘severe’ disability in the SPMS cohort (Fig. 2 ).

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To illustrate, a Canadian study identified a decreasing trend of utility loss with an EDSS increase (i.e., 0.10 utility loss for EDSS 1–2; 0.05 utility loss for EDSS 3–4; and 0.05 utility loss for EDSS 5–6) [ 36 ]; however, this study did not investigate people with MS in the severe disability category.

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