almost insignificantP = .25
[ 11 ] The early death (ED) rate acquired from 7 studies was 9% (95% CI: 7–13), including 445 patients detected by the fixed-effect model, the heterogeneity was almost insignificant ( I 2 = 24%, t 2 = 0.0276, P = .25, Figure S9, Supplemental Digital Content, http://links.lww.com/MD/J856 ).