19-21 In addition, a review including 8 studies with locally advanced or asymptomatic metastatic prostate cancer showed a nonsignificant trend in favor of early hormonal treatment in terms of OS (HR 1.23, 95% CI, 0.88-1.71). 22 Multiple types of cancer are included in this review.
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Delayed Versus Immediate Start of Chemotherapy in Asymptomatic Patients With Advanced Cancer: A Meta-Analysis.
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