Effects of a social network intervention on HIV seroconversion among people who inject drugs in Ukraine: moderation by network gender composition.

Among men in the intervention arm, the HIV seroconversion hazard rate was 21% lower with 0 network females (HR = 0.79, 95% CI = 0.55, 1.14), which was non-significant ( p = 0.213); 37% lower with 1 network female (HR = 0.63, 95% CI = 0.42, 0.92), which was significant ( p = 0.018); and 51% lower with 2 network females (HR = 0.49, 95% CI = 0.22, 1.09), which was marginally significant ( p = 0.079).

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Our first sensitivity analysis also revealed significant moderation by network gender composition even though we excluded the index, while our second sensitivity analysis showed a sustained, constant trend of reduced risk among women and a decreasing trend of reduced risk among men as the number network females increased.

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