Advances in immune checkpoint-based immunotherapies for multiple sclerosis: rationale and practice.

Cell Commun Signal · 2023 · PMC10634124 · PMID 37946301

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a decreasing trendno p-value reported

As well, according to Derakhshani et al., investigations on PBMCs of RRMS patients demonstrated a significant downregulation of VISTA mRNA expression, and further single-cell RNA sequencing analysis of various cell populations confirmed a decreasing trend in the expression pattern of VISTA in monocytes, DCs, and naïve B-cells of untreated RRMS patients compared to healthy controls [ 98 ].

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