25 Next, we determined whether this heightened sensitivity of DTA OT+/PVN mice to exogenous OT is a consequence of diminished endogenous production, as suggested by a highly significant upregulation of hypothalamic Otr mRNA (encoding for the OT receptor; Figure S1 M).
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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
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