Impact of proton pump inhibitors on the risk of small bowel or colorectal bleeding: A systematic review and meta-analysis.

United European Gastroenterol J · 2023 · PMC10637122 · PMID 37553807

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a favorable trendno p-value reported

4 Additionally, this meta‐analysis showed a favorable trend for COX‐2 inhibitors over NSAIDs and PPIs in reducing GI complications in the lower gut. 4 These results suggest that PPIs may not prevent mucosal damage in the mid‐ and lower gut.

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