CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against <i>C9ORF72</i> ALS/FTD poly-GR pathophysiology.

Sci Adv · 2023 · PMC10637751 · PMID 37948524

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highly significantno p-value reported

Treatment with 28S rRNA–based bait had a moderate but highly significant effect, reducing the severity of (GR) 36 -dependent eye degeneration and the appearance of necrotic patches (fig.

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