Statistically significant polymorphisms include: DCK 2190A>T, POLA2 2089G>A, SLC28A1 1543G>A and the highly significant polymorphs were- CDA 79A>C, CDA 208G>A, DCTD 315T>C, SLC28A1 1576T>C, SLC28A2 283A>C, TYMS 1494del. 27 Wong et al reviewed genetic polymorphisms with clinical relevance for cancer patients on gemcitabine therapy.
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Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans.
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