Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics.

Nucleic Acids Res · 2023 · PMC10639055 · PMID 37819055

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Quantification of the RHINO fluorescence intensity at the reporter gene locus of 35 cells before and after DRB treatment revealed that DRB addition results in a highly significant decrease to background values that is indicative of a robust depletion of R-loops concurrent with transcription inhibition (Figure 5G ).

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