Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome.

Analysis of RNA-seq data in CNTNAP2 CRISPRi versus control differentiated neurons showed highly significant downregulation only for CNTNAP2 (log 2 FC= −2, P -value = 1 × 10 −8 ), attesting to the specificity of the knockdown experiment (Figure 3F ) ( Supplementary Table S12 ).

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