Trends in prescription therapy for adolescents with depression in nine major areas of China during 2017-2021.

Combination therapy was the predominant pattern of treatment, monotherapy showed a decreasing trend over time ( p < 0.001), while the proportion of dual combination therapy and triple or more combination therapy kept on increasing during the 5-year period (both p < 0.001).

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At the end of the study, quetiapine and fluoxetine were the second and third most commonly prescribed drugs, respectively, and both showed an increasing trend (both p < 0.001).

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