A multicenter, randomized controlled study on the efficacy of agomelatine in ameliorating anhedonia, reduced motivation, and circadian rhythm disruptions in patients with major depressive disorder (MDD).

Ann Gen Psychiatry · 2023 · PMC10642047 · PMID 37957751

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an increasing trendno p-value reported

Analysis of changes in symptoms of anhedonia and reduced motivation in depressed patients treated with different medications As the treatment duration extended, the scores of the two groups of depressive patients treated with different medications showed a declining trend at five consecutive visit points for HAMD -17 , HAMA, SHAPS, MFI-20, and PSQI, with the exception of MEQ which showed an increasing trend.

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