RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.

Front Endocrinol (Lausanne) · 2023 · PMC10643144 · PMID 38027210

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The top 5 significantly downregulated genes in cryptorchid testis were PRM2, PRM1, TNP1, HMGB4 and LELP1 , which also showed a decreasing trend with age in normal testicular tissues, indicating their significant role in male reproduction ( Figure 3C ).

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