Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.

Nat Commun · 2023 · PMC10643470 · PMID 37957154

Europe PMC DOI

hedged sentences

0.0850

closest p · 1.7× alpha

0.0850

boldest claim

The sentences

a nonsignificant trendp = 0.085so close (0.05 < p ≤ 0.1)

3f ), with a nonsignificant trend for DOPAC ( p = 0.085, Fig. 3d ).

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highly significantno p-value reported

We now report data demonstrating that disruption of USP30 in Usp30 KO mice stimulates mitophagy and results in highly significant protection against αSyn toxicity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.