Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.

Antimicrob Agents Chemother · 2023 · PMC10648937 · PMID 37791784

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a slight trendno p-value reported

In contrast, animals with the most advanced necrotic lesions showed a slight trend toward an overall reduction in efficacy for BTZ-043, especially during the first month of treatment.

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highly significantno p-value reported

After 2 months of treatment, all BTZ-043 groups showed dose-proportional, highly significant reductions in lung burdens, with a maximal effect for the 200 mg/kg high-dose BTZ-043 study group (see Fig. 2 ).

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